Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity - Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation o...

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Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity - Nature

Source: Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes along the activation pathway and reveals structural motifs that stabilize these intermediates.